Treatment

Treatment for Primary Ovarian Insufficiency (POI)

Choose a preferred language


Primary ovarian insufficiency (POI) is when the ovaries stop working before the age of 40. With POI, an ovary does not release an egg each month as it should. This can cause symptoms and make it hard to get pregnant.


Types of treatment

POI can be treated in different ways. Most people with POI need hormone treatment with estrogen. This can help reduce bone loss and other symptoms, such as vaginal dryness. You may also be given progesterone. This is for those who haven't had surgery to remove their uterus (hysterectomy).

In some people, treatment of another health condition may help treat POI. For example, treatment of thyroid disease or an eating disorder may reduce POI symptoms.

Pregnancy rates for those with POI are low. If you have POI and still want to get pregnant, your doctor may advise:

  • Using a donor egg instead of your own egg
  • Estrogen therapy as part of a combined hormonal treatment

A small number of people with POI can get pregnant naturally. Talk with your doctor about birth control if you want to prevent pregnancy.


Living with POI

Some people are upset to learn that they have POI, especially if they still want children. This can lead to depression and anxiety. Talking with a mental health care provider may help.

POI can also lead to thin, weak bones (osteoporosis). Osteoporosis can increase your chances of a broken bone. Your doctor may give you advice to help keep your bones healthy. This may include:

  • Taking extra calcium and vitamin D
  • Quitting smoking
  • Exercising more

Featured in

© 2000-2026 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
Related Articles
Read article
OB/GYN
Treating Pelvic Inflammatory Disease (PID) With Medicines

As soon as PID has been diagnosed, it should be treated with antibiotics. Two or more types of antibiotics may be taken at the same time. This ensures that all the bacteria are killed. It's very important to take all of your medicine as prescribed, or the infection may not go away.

Read article
OB/GYN
Understanding Ovarian Cystectomy

An ovarian cystectomy is a surgery that removes a cyst from your ovaries. It's usually done only if the cyst is large or painful.

Read article
OB/GYN
Having Robotic-Assisted Myomectomy

Robotic-assisted myomectomy is a type of surgery. It's done to remove growths in a women's womb (uterus) called fibroid tumors. The tumors are not cancer. The surgery is done with special tools and a robotic controller.

Read article
OB/GYN
Understanding Laparoscopic Surgery for Ovarian Torsion

This surgery fixes an ovary that has twisted. When such twisting happens, it's called ovarian torsion.